6-Aminopicolinic Acid Ethyl Ester
Ethyl 6-aminopyridine-2-carboxylate
CAS: 69142-64-9
Molecular Formula: C8H10N2O2
6-Aminopicolinic Acid Ethyl Ester - Names and Identifiers
6-Aminopicolinic Acid Ethyl Ester - Physico-chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molar Mass | 166.18 |
| Density | 1.192 |
| Melting Point | 56-58℃ |
| Boling Point | 330℃ |
| Flash Point | 153℃ |
| Solubility | soluble in Methanol |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Yellow to Green |
| Maximum wavelength(λmax) | ['337nm(MeOH)(lit.)'] |
| pKa | 1.87±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.559 |
6-Aminopicolinic Acid Ethyl Ester - Introduction
Ethyl 6-aminopyridine-2-carboxylate is an organic compound with the chemical formula C9H11N3O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Ethyl 6-aminopyridine-2-carboxylate is a white to light yellow crystal or crystalline powder.
-Solubility: It is insoluble in water, but soluble in organic solvents (such as ethanol, chloroform, dimethylformamide, etc.).
-Melting point: Its melting point is about 130-134 degrees Celsius.
Use:
- Ethyl 6-aminopyridine-2-carboxylate is widely used in the synthesis of biologically active organic molecules in the field of medicinal chemistry.
-It is an intermediate for the preparation of a variety of drugs and biologically active compounds, especially for the synthesis of pyridine drugs.
Preparation Method:
- Ethyl 6-aminopyridine-2-carboxylate can be synthesized by the following steps:
1. Ethyl 2-chloroacetate and 6-aminopyridine were esterified in the presence of sodium carbonate.
2. After the esterification reaction is completed, carry out crystallization purification to obtain Ethyl 6-aminopyridine-2-carboxylate product.
Safety Information:
- Ethyl 6-aminopyridine-2-carboxylate's chemical safety instructions should be followed, including proper use and storage methods.
-It is an organic compound with certain toxicity and direct contact with skin and eyes should be avoided.
-Use appropriate personal protective equipment such as lab gloves, safety glasses, etc.
-If swallowed or inhaled, seek medical attention immediately.
Nature:
-Appearance: Ethyl 6-aminopyridine-2-carboxylate is a white to light yellow crystal or crystalline powder.
-Solubility: It is insoluble in water, but soluble in organic solvents (such as ethanol, chloroform, dimethylformamide, etc.).
-Melting point: Its melting point is about 130-134 degrees Celsius.
Use:
- Ethyl 6-aminopyridine-2-carboxylate is widely used in the synthesis of biologically active organic molecules in the field of medicinal chemistry.
-It is an intermediate for the preparation of a variety of drugs and biologically active compounds, especially for the synthesis of pyridine drugs.
Preparation Method:
- Ethyl 6-aminopyridine-2-carboxylate can be synthesized by the following steps:
1. Ethyl 2-chloroacetate and 6-aminopyridine were esterified in the presence of sodium carbonate.
2. After the esterification reaction is completed, carry out crystallization purification to obtain Ethyl 6-aminopyridine-2-carboxylate product.
Safety Information:
- Ethyl 6-aminopyridine-2-carboxylate's chemical safety instructions should be followed, including proper use and storage methods.
-It is an organic compound with certain toxicity and direct contact with skin and eyes should be avoided.
-Use appropriate personal protective equipment such as lab gloves, safety glasses, etc.
-If swallowed or inhaled, seek medical attention immediately.
Last Update：2024-04-09 02:00:47
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View History
6-Aminopicolinic Acid Ethyl Ester
1H-吲唑-3-甲醛盐酸盐
4-碘-3,5-二甲基苯甲酰胺
(2-oxo-2-phenylmethoxyethyl)-triphenylphosphonium bromide
acetate-cyclohexano
特戊酸酐
Kanamycin Sulfate Salt
2-PYRIDIN-3-YL-5-(TRIFLUOROMETHYL)AZEPANE
2443708-99-2
1597532-47-2
1H-吲唑-3-甲醛盐酸盐
4-碘-3,5-二甲基苯甲酰胺
(2-oxo-2-phenylmethoxyethyl)-triphenylphosphonium bromide
acetate-cyclohexano
特戊酸酐
Kanamycin Sulfate Salt
2-PYRIDIN-3-YL-5-(TRIFLUOROMETHYL)AZEPANE
2443708-99-2
1597532-47-2